Cdc48/p97, a ubiquitin-selective chaperone, orchestrates the function of E3 ligases and deubiquitylases (DUBs).Here, redken shades 9gi we identify a new function of Cdc48 in ubiquitin-dependent regulation of mitochondrial dynamics.The DUBs Ubp12 and Ubp2 exert opposing effects on mitochondrial fusion and cleave different ubiquitin chains on the mit
Background/Aims Despite the U.S.Food and Drug Adminstration approving a magnetic resonance imaging (MRI)-conditional pacemaker system in 2011, many physicians remain reluctant to perform MRI scanning in patients with cardiac implantable electronic devices.Herein, we aimed to evaluate the real-world safety of MRI in these patients.Methods This singl
Abstract Dependence is a hallmark of alcohol use disorder characterized by excessive alcohol intake and withdrawal symptoms.The central nucleus of the amygdala (CeA) is a key brain structure underlying the synaptic and behavioral consequences of ethanol dependence.While accumulating evidence suggests that astrocytes regulate synaptic transmission a